Focused on Diseases of Malabsorption and Nutrient Metabolism
At Anagram, we are developing a pipeline of products that use the power of orally delivered enzymes as therapeutics to solve complex problems. We are leveraging our team’s decades of experience in gastrointestinal diseases and novel enzyme technologies to advance a pipeline of orally delivered enzyme products that have the potential to make a life-changing impact for people and their families living with rare diseases.
Malabsorption syndromes and nutrient metabolism disorders are a group of conditions caused by enzyme deficiencies or genetic mutations that prevent the body from properly metabolizing or absorbing certain fats, carbohydrates, simple sugars, proteins, vitamins, or other key nutrients. These conditions affect infants, children, and adults worldwide — both those born with congenital rare diseases and those who develop malabsorption syndromes as part of another illness.
From developing new therapies to engaging with patient communities, everything we do focuses on what matters most to those living with rare diseases.
Significant GI Symptoms
Steatorrhea, constipation, nausea, abdominal pain, bloating, gas, diarrhea
Weight Loss and Growth Impediment
Weight loss, wasting and fatigue are common and pronounced; these symptoms are independent predictors of survival
Fatty Acid, Carbohydrate, and Protein Abnormalities
Play a central role in severity of symptoms and disease progression
Increased Morbidity and Reduced QoL
Worsens clinical outcomes; adds to the overall costs of care and dramatic impact to quality of life
Reduced Life-Expectancy
Directly impacts survival in rare disease, cancer and pancreatitis
Metabolic Challenges
Increased inflammation, vitamin deficiencies, reduced bone mineral metabolism and ultimately organ failure