Pipeline
Advancing Best-in-Class Enzyme Therapies
Anagram’s ANG003: A Novel Class of Enzyme Replacement
Our lead product, ANG003, is a novel, microbially-derived, broad spectrum combination of lipase (for fats), protease (for protein) and amylase (for carbohydrate). This breakthrough oral therapy is currently in clinical trial in people with cystic fibrosis, and has additional therapeutic potential in gastrointestinal disease and digestive cancer.
Malabsorption of macronutrients
leads to devastating consequences:
Debilitating
GI Symptoms
Steatorrhea, constipation, nausea, abdominal pain, bloating, gas, diarrhea
Weight Loss and
Growth Impediment
Weight loss, wasting and fatigue are common and pronounced; independent predictor of survival
Fatty Acid, Carbohydrate,
and Protein Abnormalities
Play a central role in severity of symptoms and disease progression
Increased Morbidity and
Reduced QoL
Worsens clinical outcomes; adds to the overall costs of care and dramatic impact to QoL
Reduced Life-Expectancy
Directly impacts survival in rare disease, cancer and pancreatitis
Metabolic Challenges
Increased inflammation, vitamin deficiencies, reduced bone mineral metabolism and ultimately organ failure
At Anagram, we are developing a deep pipeline of products that use the power of orally delivered enzymes as therapeutics to solve complex problems.
Click the + to get details on each candidate.
malabsorption syndromes
New class of enzyme replacement therapy providing unparalleled performance with broad-spectrum composition (lipase for fat, protease for protein, amylase for carbohydrate) to make a life-changing impact for people who require oral ERT.
Engineered to break down specific carbohydrates due to enzyme deficiencies to avoid the severe complications associated with carbohydrate malabsorption.
Engineered to break down specific carbohydrates abnormalities due to pancreatic dysfunction to avoid the complications associated with carbohydrate malabsorption.
Engineered to break down specific carbohydrates to avoid buildup in the body of toxic complications associated with carbohydrate malabsorption.